UserFriendly

http://userfriendly.org/

Daily strip about a bunch of people working at an Internet Company.
If you are a geek, this the one strip you have to read. There is a full archive online.

GPF - General Protection Fault
http://www.gpf-comics.com/ is another 'geeky'
strip. However, even the non-initated can understand the strip. Pretty funny! Here again
the online archive.

Sluggy

This is the story of a few people who end up in the most bizare situations. Fun to read, good drawings! The archive is here.

Dilbert

http://dilbert.com

This strip should need no introduction. Daily strip about a coporate IT department.
This does not have a complete archive, but you can see a months worth of the script.

Betty
http://comics.com/comics/betty/

A portrait about an modern american family. Nice observations ...
This does not have a complete archive, but you can see a months worth of the script.

Get Fuzzy
http://comics.com/comics/getfuzzy/

Life from the perpectives of a cat, a dog, and Rob who owns/parents them.
This does not have a complete archive, but you can see a months worth of the script.

Real Life
www.reallifecomics.com/
3 housemates and their friends. Their life. Computers, games ....

Sheldon

http://www.sheldoncomics.com/
A 10-year old software billionare, his talking duck, and his grandfather.
Plus a couple other funny characters

Sinfest

http://www.sinfest.net/
Way good strip! Good and Evil, Slick and Monique, the cat and the dog, heaven and hell ...

Freefall

http://www.purrsia.com/freefall/
The Story of an alien, his robot and their mechanic wolf.

kevin and kell

Years ago, Kevin Kindle the rabbit and Kell Dewclaw the wolf met in an online chat room.
After falling head over heels for each other, they decided to meet in person. It wasn't
until then that they realized they were from separate ends of the food chain...